This work was the ground layer for the later Tracy Putnam work in the vascular theory of MS.
3.
He was one of the first proposers of a vascular theory for multiple sclerosis after noticing in 1863 that the inflammation-associated lesions were distributed around veins.
4.
The term " cerebrovascular accident " was introduced in 1927, reflecting a " growing awareness and acceptance of vascular theories and ( . . . ) recognition of the consequences of a sudden disruption in the vascular supply of the brain ".
5.
This vascular theory, which was developed in the 20th century by Wolff, suggested that the aura in migraines is caused by constriction of intracranial vessels ( vessels inside the brain ), and the headache itself is caused by rebound dilation of extracranial vessels ( vessels just outside the brain ).
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